Stimulation of Respiration in Brown Fat Cells by Epinephrine, Dibutyryl-3′,5′-adenosine Monophosphate, and m-Chloro(carbonyl Cyanide)phenylhydrazone
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چکیده
منابع مشابه
Dibutyryl Cyclic Adenosine Monophosphate Reduces
The human promyelocytic leukemia cell line HL-60 is induced to differentiate along a myelocytic pathway by dibutyryl cyclic adenosine monophosphate (dbcAMP). Other cAMP analogs are ineffective as inducing agents. The effect of these compounds on expression of c-myc was investigated using a DNA probe for c-myc to detect RNA transcripts. The dose response and time to commitment for reduction in c...
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The omission of K+ from the buffer used for isolation and it .cubation of rat brown fat cells blocked the large increases in respiration seen after the addition of lipolytic agents. The effect of K+ was on the activation of respiration by free fatty acids rather than upon the lipolytic action of agents such as theophylline. Rb+ and Cs+, but not NH4+, could partially substitute for K+ in the act...
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1. A technique was devised for ready sequential sampling of lipocyte suspensions for measurement of metabolic activities. 2. With the use of this technique in paired incubations, an effect of oligomycin to decrease the Qo, of fat cells to 45% of control was shown. 3. An analogy between the effect of oligomycin on intact cells and that described for isolated mitochondria was suggested, since the...
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Treatment of Chinese hamster ovary cells in vitro with dibutyrl adenosine cyclic 3':5'-monophosphate converts the culture from one of compact, randomly oriented cells that grow in multilayers to a monolayer of elongated, fibroblast-like cells growing parallel to one another. Testosterone propionate, which has a similar though smaller effect at high concentrations and after prolonged incubation,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93348-x